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Before Your Procedure GLP-1 Medication Instructions

An implication of these medications is slowing the emptying of the stomach. This poses a risk for patients receiving anesthesia, as it cannot be administered if the stomach is not empty. Holding these medications before an elective surgery or procedure will decrease the risk of complications associated with anesthesia.

For Daily oral or tablet dosing hold your GLP-1 agonist on the day of your procedure examples include:

  • Adlyxin or Lixisenatide
  • Byetta or Bydureon® or Exentatide IR
  • Liraglutide or Victoza
  • Rybelsus or Semaglutide

For Daily injectable Lixisenatide (Adlyxin®), hold your GLP-1 agonist on the day of your procedure.

For Weekly injectable dosing, hold your GLP-1 agonist at least one week (7 days) prior to your procedure, examples include:

  • Bydureon or Exenatide
  • Ozempic or Wegovy or Semaglutide
  • Tirzepatide (Mounjaro™)
  • Trulicity or Dulaglutide

For the weekly injectables you must be medication-free for at least a week. Unless your procedure day is the same as your dosing day, you will be off your medication for more than a week.

If your GLP-1 agonist is prescribed for diabetes management and is stopped for longer than the dosing schedule, you may need to see your prescribing physician for interim medication to avoid the risk of high blood sugar before your procedure.

If you are unsure, please check with your prescribing provider.